Degradation of Trimethoprim

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 1989 English Publisher:Elsevier BVJournal:Journal of Pharmaceutical Sciences, volume 78, pages 348-350 (issn: 0022-3549,

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Authors: J J, Bergh; J C, Breytenbach; P L, Wessels;

doi: 10.1002/jps.2600780418

pmid: 2724100

Degradation of Trimethoprim

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Abstract

Trimethoprim undergoes thermally and photochemically catalyzed hydrolysis or oxidation to give rise to at least five products. The structures of these compounds were determined by physical methods and it was found that the resonance of C-5 in the 13C NMR spectrum is indicative of the substitution pattern of the resultant amino hydroxy pyrimidines.

Related Organizations

Potchefstroom University for Christian Higher Education
South Africa
North-West University
South Africa

Keywords

Chemistry, Magnetic Resonance Spectroscopy, Chemical Phenomena, Isomerism, Photochemistry, Hydrolysis, Hydrogen-Ion Concentration, Mass Spectrometry, Trimethoprim

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