Physical Characterization of the Hydrates of Urapidil

descriptionPublicationkeyboard_double_arrow_right Article 01 May 1988 English Publisher:Elsevier BVJournal:Journal of Pharmaceutical Sciences, volume 77, pages 444-451 (issn: 0022-3549,

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Authors: S A, Botha; M R, Caira; J K, Guillory; A P, Lötter;

doi: 10.1002/jps.2600770518

pmid: 3411469

Physical Characterization of the Hydrates of Urapidil

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Abstract

Three hydrates of urapidil were prepared and characterized by means of differential scanning calorimetry, thermogravimetric analysis, infrared spectroscopy, X-ray powder diffraction, intrinsic dissolution rates, and solution calorimetry. The stoichiometry of the urapidil hydrates was found to be 1:5, 1:3, and 1:1 (urapidil:water). The crystal and molecular structures of urapidil pentahydrate were determined from three-dimensional X-ray data. The stability of the pentahydrate and monohydrate under different storage conditions was also determined.

Related Organizations

University of Port Elizabeth
South Africa
Carlow University
United States
North-West University
South Africa

Keywords

Crystallography, Differential Thermal Analysis, Chemical Phenomena, Spectrophotometry, Infrared, Chemistry, Physical, Stereoisomerism, Piperazines, Drug Stability, Solubility, X-Ray Diffraction, Microscopy, Electron, Scanning

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