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Isopilocarpine Binding to Muscarinic Cholinergic Receptors

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 1986Publisher:Elsevier BVJournal:Journal of Pharmaceutical Sciences, volume 75, pages 278-279 (issn: 0022-3549,

Authors: James J. O'Donnell; Jon R. Polansky; Michael V. Drake;

doi: 10.1002/jps.2600750315

pmid: 3701611

Isopilocarpine Binding to Muscarinic Cholinergic Receptors

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Abstract

Isopilocarpine coexists with pilocarpine in nature, and it is present in varying degrees in commercial pilocarpine preparations. Using muscarinic cholinergic receptors from bovine ciliary muscle tissue, we measured the relative binding affinity of isopilocarpine and pilocarpine. The binding affinity of isopilocarpine was approximately one-tenth that of pilocarpine. Because of the relatively low concentration of isopilocarpine found in commercial pilocarpine preparations, and the low binding affinity of isopilocarpine for the muscarinic receptors, the practical effect of isopilocarpine contamination is small.

Related Organizations

University of California System
United States
University of California, San Francisco
United States

Keywords

Quinuclidinyl Benzilate, Kinetics, Pilocarpine, Animals, Cattle, Muscle, Smooth, In Vitro Techniques, Eye, Receptors, Muscarinic

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