Pharmacokinetics of Transdermal Drug Delivery

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 1985 English Publisher:Elsevier BVJournal:Journal of Pharmaceutical Sciences, volume 74, pages 718-721 (issn: 0022-3549,

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Authors: B, Berner;

doi: 10.1002/jps.2600740704

pmid: 3928870

Pharmacokinetics of Transdermal Drug Delivery

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Abstract

The pharmacokinetics of drug delivery from transdermal controlled-release devices consisting of (a) a membrane plus a reservoir or (b) a monolithic slab are examined. For the period when the devices act as if the drug reservoir were infinite, simple relationships for the steady-state slope and time lag are derived and studied. An analysis of the time region when depletion of the finite dose is obtained is used to estimate the useful device lifetime. Applications to patch design are discussed.

Keywords

Kinetics, Nitroglycerin, Pharmaceutical Preparations, Administration, Topical, Skin Absorption, Scopolamine, Humans

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