Synthesis and Pharmacological Evaluation of Aromatic Dihydroxylated Spiro[indan-1,3′-pyrrolidine] and Spiro[indan-2,2′-pyrrolidine] Derivatives
Copyright policy ) R, Sommerville; H E, Rosenberg; P A, Crooks;
Synthesis and Pharmacological Evaluation of Aromatic Dihydroxylated Spiro[indan-1,3′-pyrrolidine] and Spiro[indan-2,2′-pyrrolidine] Derivatives
Aromatic hydroxylated derivatives of the spiro[indan-1,3'-pyrrolidine] and spiro[indan-2,2'-pyrrolidine] ring systems have been synthesized and evaluated for dopaminergic agonist and antagonist activities. None of these conformationally restricted catecholamines possessed any dopaminergic activity, but 5,6-dihydroxy spiro[indan-1,3'-pyrrolidine] hydrobromide exhibited weak dopamine antagonist properties.
- University of Manchester United Kingdom
Chemistry, Pyrrolidines, Apomorphine, Chemical Phenomena, Tetrahydronaphthalenes, Animals, Corpus Striatum, Body Temperature, Rats, Receptors, Dopamine
Chemistry, Pyrrolidines, Apomorphine, Chemical Phenomena, Tetrahydronaphthalenes, Animals, Corpus Striatum, Body Temperature, Rats, Receptors, Dopamine
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These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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