Powered by OpenAIRE graph
Found an issue? Give us feedback
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Journal of Pharmaceu...arrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Journal of Pharmaceutical Sciences
Article . 1984 . Peer-reviewed
License: Elsevier TDM
Data sources: Crossref
versions View all 2 versions
addClaim

Neutron Activation of Iron Tablets to Evaluate the Effects of Glycine on Iron Absorption

Authors: J M, Christensen; M, Ghannam; J W, Ayres;

Neutron Activation of Iron Tablets to Evaluate the Effects of Glycine on Iron Absorption

Abstract

Neutron bombardment (neutron flux, 3 X 10(12) neutrons/cm2/s) of prepared iron tablets containing glycine-iron or iron alone was performed to prepare radioactive tablets to assess the effects of glycine on iron absorption from tableted formulations. No interfering isotopes of sufficient quantity were generated during neutron activation of the iron tablets. Cobalt-60 was the major trace mineral detected and accounted for only 1.3% of the total activity. There may have been trace amounts of zinc-65 or chromium-51 present, but they were not detectable above background radioactivity in the final tablet produced. Iron-59 represented greater than 98% of the radioactivity present in the tablets used in the study. Glycine-containing iron tablets produced dramatically higher amounts of iron in blood and tissues of rabbits (p less than 0.05) than did the same tablet formulations without glycine. The area under the iron blood concentration-time curve over 4 h increased by 67% with glycine added to the formulation over control iron tablets. Iron concentrations in tissues 4 h after iron administration was in the order of blood greater than liver greater than heart greater than kidney greater than muscle.

Related Organizations
Keywords

Intestinal Absorption, Iron, Glycine, Animals, Female, Tissue Distribution, Ferrous Compounds, Neutron Activation Analysis, Rabbits, Tablets

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    5
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
Powered by OpenAIRE graph
Found an issue? Give us feedback
selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
5
Average
Top 10%
Average
Upload OA version
Are you the author of this publication? Upload your Open Access version to Zenodo!
It’s fast and easy, just two clicks!