
Data are reported on the analytical and physicochemical characteristics of amiodarone, for use in identifying and/or assaying this antiarrhythmic agent. The drug is highly soluble in chloroform and poorly soluble in water. Its acid-base constant (pKa) is 6.56, and its maximal lipid solubility range is from pH 3.5 to 5.5.
Chemical Phenomena, Spectrophotometry, Infrared, Chemistry, Physical, physicochemical characteristics, Amiodarone, antiarrhythmic agent, Hydrogen-Ion Concentration, amiodarone; antiarrhythmic agent; physicochemical characteristics, Mass Spectrometry, Solubility, Solvents, Spectrophotometry, Ultraviolet, amiodarone, Chromatography, High Pressure Liquid, Benzofurans
Chemical Phenomena, Spectrophotometry, Infrared, Chemistry, Physical, physicochemical characteristics, Amiodarone, antiarrhythmic agent, Hydrogen-Ion Concentration, amiodarone; antiarrhythmic agent; physicochemical characteristics, Mass Spectrometry, Solubility, Solvents, Spectrophotometry, Ultraviolet, amiodarone, Chromatography, High Pressure Liquid, Benzofurans
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