Epimerization of Benzylpenicilloic Acid in Alkaline Media
Copyright policy )Epimerization of Benzylpenicilloic Acid in Alkaline Media
5R,6R-Benzylpenicilloic acid was found to epimerize slowly in alkaline media to 5S,6R-benzylpenicilloic acid until equilibrium was established. Epimerization proceeded via the imine tautomer of penamaldic acid rather than the enamine form and was found to favor the 5S,6R-epimer at equilibrium. The conversion process was monitored using both reverse-phase high-performance liquid chromatography and NMR spectroscopy.
- Purdue University West Lafayette United States
- Purdue University System United States
Chemistry, Magnetic Resonance Spectroscopy, Chemical Phenomena, Penicillin G, Spectrophotometry, Ultraviolet, Stereoisomerism, Hydrogen-Ion Concentration, Chromatography, High Pressure Liquid, Polarography
Chemistry, Magnetic Resonance Spectroscopy, Chemical Phenomena, Penicillin G, Spectrophotometry, Ultraviolet, Stereoisomerism, Hydrogen-Ion Concentration, Chromatography, High Pressure Liquid, Polarography
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).36 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!