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Metabolism of Imipramine by Microorganisms

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 1981Publisher:Elsevier BVJournal:Journal of Pharmaceutical Sciences, volume 70, pages 151-155 (issn: 0022-3549,

Authors: Alice M. Clark; John K. Baker; George A. Capiton; Charles D. Huffordx;

doi: 10.1002/jps.2600700209

pmid: 7205217

Metabolism of Imipramine by Microorganisms

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Abstract

The microbial metabolism of imipramine was studied using selected fungal organisms. The major microbial metabolites were isolated, and their structures were established by spectroscopic analyses (particularly 13C-NMR) and by comparison with authentic samples. The microbial metabolites identified included 2-hydroxyimipramine, 10-hydroxyimipramine, iminodibenzyl, imipramine-N-oxide, and desipramine; these metabolites also have been found in mammalian metabolism studies.

Related Organizations

University of Mississippi
United States

Keywords

Imipramine, Fermentation, Fungi, Biotransformation

1 Research products, page 1 of 1

Role of P450IID6, the target of the sparteine-debrisoquin oxidation polymorphism, in the metabolism of imipramine
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