Degradation of Chlorambucil in Aqueous Solution

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 1980 English Publisher:Elsevier BVJournal:Journal of Pharmaceutical Sciences, volume 69, pages 1,091-1,094 (issn: 0022-3549,

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Authors: H, Ehrsson; S, Eksborg; I, Wallin; S O, Nilsson;

doi: 10.1002/jps.2600690928

pmid: 7411416

Degradation of Chlorambucil in Aqueous Solution

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Abstract

The stability of chlorambucil and its degradation product 4-[p-(2-chloroethyl-2-hydroxyethylamino)phenyl]butyric acid (I) was studied using reversed-phase high-pressure liquid chromatography. The degradation rate of chlorambucil was unaffected by pH between pH 5 and 10 but decreased at lower pH. The degradation rates of chlorambucil and I differed only slightly (pH < 6). The proteolytic properties of the compounds were studied using spectrophotometric and partition techniques.

Keywords

Solutions, Chemistry, Kinetics, Chemical Phenomena, Drug Stability, Chlorambucil, Hydrogen-Ion Concentration

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