Improved Delivery of Methoxsalen

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 1979 English Publisher:Elsevier BVJournal:Journal of Pharmaceutical Sciences, volume 68, pages 451-454 (issn: 0022-3549,

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Authors: J, Kreuter; T, Higuchi;

doi: 10.1002/jps.2600680415

pmid: 438967

Improved Delivery of Methoxsalen

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Abstract

Significant improvement in the effective bioavailability of methoxsalen was achieved when it was administered to rats and dogs in a solution as compared to a suspension. Much earlier and higher peak levels were observed for the solution in both animals. The possible impact of these observations on current use of this agent for psoriasis treatment is discussed.

Related Organizations

University of Kansas
United States

Keywords

Male, Administration, Oral, Biological Availability, Capsules, Models, Biological, Rats, Solutions, Dogs, Suspensions, Injections, Intravenous, Animals, Methoxsalen, Chromatography, High Pressure Liquid

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