Flow Rates and Repose Angles of Wet-Processed Granulations

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 1977 English Publisher:Elsevier BVJournal:Journal of Pharmaceutical Sciences, volume 66, pages 1,235-1,238 (issn: 0022-3549,

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Authors: J T, Carstensen; P C, Chan;

doi: 10.1002/jps.2600660907

pmid: 903857

Flow Rates and Repose Angles of Wet-Processed Granulations

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Abstract

The equation of McDougall and Evans was found not to apply to granulations. The functional relationships among volumetric powder flow rates, angles of repose, and particle size were demonstrated to exhibit maxima (rather than minima) in five common pharmaceutical granulations produced by wet processing. The angular behavior of granules (such as the experienced range of angles) is explained via supported stacking geometries, and the shallow maxima in the angle of repose versus granule diameter was derived from this model.

Related Organizations

University of Wisconsin–Madison
United States

Keywords

Models, Chemical, Chemistry, Pharmaceutical, Drug Compounding, Particle Size, Powders

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