Determination of Oxamniquine in Serum

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 1977 English Publisher:Elsevier BVJournal:Journal of Pharmaceutical Sciences, volume 66, pages 429-430 (issn: 0022-3549,

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Authors: N M, Woolhouse; P R, Wood;

doi: 10.1002/jps.2600660331

pmid: 845813

Determination of Oxamniquine in Serum

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Abstract

A method for the analysis of oxamniquine in serum (or plasma), sensitive to 10 ng/ml, was developed. Oxamniquine and a close structural analog as the internal standard were extracted from serum with ether. After derivatization with N,O-bis(trimethylsilyl)acetamide, oxamniquine was determined as its trimethylsilyl ether derivative by GLC using an electron-capture detector. The method was developed to study serum concentration profiles of different dosage forms of oxamniquine.

Related Organizations

Pfizer (United States)
United States

Keywords

Chromatography, Gas, Time Factors, Methods, Animals, Humans, Nitroquinolines, Oxamniquine

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