Electrode Sensitive to Sulfa Drugs

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 1976 English Publisher:Elsevier BVJournal:Journal of Pharmaceutical Sciences, volume 65, pages 435-436 (issn: 0022-3549,

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Authors: N, Hazemoto; N, Kamo; Y, Kobatake;

doi: 10.1002/jps.2600650332

pmid: 4602

Electrode Sensitive to Sulfa Drugs

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Abstract

An electrode sensitive to sulfa drugs was constructed by using the iron(II)-bathophenanthroline chelate embedded in a liquid membrane. Rapid and Nernstian responses were exhibited against solutions of sulfamerazine and sulfisomidine ranging between 10(-3) and 10(-1) M in concentration. High selectivity was observed in the presence of urea, glycine, aminopyrine, or p-amino-benzoic acid. These chemicals are known to interfere in the usual colorimetric analysis of sulfa drugs.

Related Organizations

Hokkaido University
Japan
Hokkaido Bunkyo University
Japan

Keywords

Chemistry, Chemical Phenomena, Sulfisomidine, Methods, Hydrogen-Ion Concentration, Electrodes, Sulfamerazine

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