Dehydration of Tetracycline

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 1975 English Publisher:Elsevier BVJournal:Journal of Pharmaceutical Sciences, volume 64, pages 352-354 (issn: 0022-3549,

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Authors: K D, Schlecht; C W, Frank;

doi: 10.1002/jps.2600640241

pmid: 1127597

Dehydration of Tetracycline

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Abstract

The dehydration of tetracycline at the C-5a-C-6 position as a function of acidity was investigated at various temperatures. The rate was first order with respect to tetracycline and with respect to [H+]. Rate constants and an activation energy are reported. Tetracycline was unstable in dilute acid.

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Keywords

Chemistry, Kinetics, Chemical Phenomena, Temperature, Spectrophotometry, Ultraviolet, Chromatography, Thin Layer, Tetracycline, Anhydrides

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