Diphenylhydantoin Microdetermination in Serum and Plasma by UV Spectrophotometry
Copyright policy )Diphenylhydantoin Microdetermination in Serum and Plasma by UV Spectrophotometry
Abstract: A modified UV spectrophotometry procedure for determining diphenylhydantoin in 0.1-0.2 ml of serum is described. Improvement of previously described techniques was accomplished by modifying the extraction conditions and refluxing assembly. Continuous extraction of the oxidized diphenylhydantoin provided the maximum yield of benzophenone, resulting in optimal sensitivity as well as reproducibility of analytical values. Reliable clinical assays are achieved on 0.1 ml of serum containing 0.5 μg of diphenylhydantoin. Recovery of the drug from biological fluids is approximately 94%.
Benzophenones, Potassium Permanganate, Microchemistry, Phenytoin, Methods, Humans, Spectrophotometry, Ultraviolet, Oxidation-Reduction
Benzophenones, Potassium Permanganate, Microchemistry, Phenytoin, Methods, Humans, Spectrophotometry, Ultraviolet, Oxidation-Reduction
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