Colorimetric Assay of Epinephrine

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 1974 English Publisher:Elsevier BVJournal:Journal of Pharmaceutical Sciences, volume 63, pages 1,301-1,302 (issn: 0022-3549,

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Authors: R B, Salama; S K, Khalil;

doi: 10.1002/jps.2600630832

pmid: 4851081

Colorimetric Assay of Epinephrine

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Abstract

A new colorimetric assay method for epinephrine, based on the reaction with thiosemicarbazide in alkaline medium, is presented. Beer's law is followed in the range of 25–300 μg. Data on precision, accuracy, and specificity are included. A special calculation is adopted in the presence of norepinephrine. The method, because of its simplicity, is particularly suited for routine analysis of official preparations of epinephrine.

Related Organizations

University of Khartoum
Sudan
University of South Dakota
United States

Keywords

Thiosemicarbazones, Epinephrine, Catechols, Temperature, Hydrogen-Ion Concentration, Methylation, Adrenochrome, Norepinephrine, Benzene Derivatives, Methods, Colorimetry, Indicators and Reagents

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