Biotransformation of Isosorbide Dinitrate in Humans
Copyright policy )Biotransformation of Isosorbide Dinitrate in Humans
An oral dose of 14C-isosorbide dinitrate was rapidly absorbed and eliminated by human subjects. Up to 99% was excreted in the urine. The drug was completely biotransformed, nearly 50% to the principal metabolite, an isosorbide conjugate, presumably with glucuronic acid. Up to 13% was excreted as free and conjugated 5-isosorbide mononitrate, and 1% was excreted as the free 2-isosorbide mononitrate only. D-Sorbitol possibly accounted for a further 18% of the radioactivity; an unknown metabolite, less polar than isosorbide, accounted for 6%.
Feces, Time Factors, Autoradiography, Humans, Carbon Radioisotopes, Chromatography, Thin Layer, Isosorbide Dinitrate, Biotransformation, Half-Life
Feces, Time Factors, Autoradiography, Humans, Carbon Radioisotopes, Chromatography, Thin Layer, Isosorbide Dinitrate, Biotransformation, Half-Life
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