Synthesis of Peptides Contahng Aminophosphonic Acids

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 1974 English Publisher:Elsevier BVJournal:Journal of Pharmaceutical Sciences, volume 63, pages 1,087-1,090 (issn: 0022-3549,

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Authors: W F, Gilmore; H A, McBride;

doi: 10.1002/jps.2600630711

pmid: 4854578

Synthesis of Peptides Contahng Aminophosphonic Acids

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Abstract

Dipeptides containing C-terminal α-aminobenzylphosphonic acid were prepared in both aqueous and nonaqueous media. The synthesis of intermediates necessary for the preparation of peptides containing α-aminophosphonic acids is also discussed. Similarities and differences in coupling aminophosphonic and aminocarboxylic acids by means of dicyclohexylcarbodiimide, acyl chlorides, and 1-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline are described.

Related Organizations

University of Mississippi
United States

Keywords

Magnetic Resonance Spectroscopy, Chemical Phenomena, Spectrophotometry, Infrared, Carboxylic Acids, Glycine, Organophosphonates, Dioxins, Carbodiimides, Chemistry, Chlorides, Methods, Quinolines, Peptides

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