Nonsink Dissolution Rate Equation

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 1973 English Publisher:Elsevier BVJournal:Journal of Pharmaceutical Sciences, volume 62, pages 1,468-1,470 (issn: 0022-3549,

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Authors: P, Pothisiri; J T, Carstensen;

doi: 10.1002/jps.2600620916

pmid: 4743094

Nonsink Dissolution Rate Equation

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Abstract

An equation was developed which describes the dissolution of monodisperse particles beyond the point where concentrations are small compared to solubility. If it is assumed that a stagnant layer model applies, the thickness of these layers is of the same order of magnitude as calculated via the Hixson-Crowell treatment but dissolution rate constants are 1.5-2 times as large. The application of the equation to dissolution of hydrocortisone, levodopa, and p-hydroxybenzoic acid is shown.

Related Organizations

University of Wisconsin–Madison
United States

Keywords

Kinetics, Hydrocortisone, Solubility, Spectrophotometry, Ultraviolet, Benzoates, Mathematics, Dihydroxyphenylalanine

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