Migration of Potent Drugs in Wet Granulations

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 1972 English Publisher:Elsevier BVJournal:Journal of Pharmaceutical Sciences, volume 61, pages 1,121-1,125 (issn: 0022-3549,

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Authors: I A, Chaudry; R E, King;

doi: 10.1002/jps.2600610718

pmid: 5044813

Migration of Potent Drugs in Wet Granulations

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Abstract

Sodium warfarin tablets prepared by a wet granulation method were shown to be unsatisfactory as to content uniformity due to the migration of the drug substance during the drying period. By using a TLC method, additives were selected which inhibited the migration of the drug substance. The use of these additives with sodium warfarin gave satisfactory tablets as to content uniformity when a wet granulation method was employed.

Related Organizations

University of the Sciences
United States

Keywords

Drug Compounding, Pharmaceutic Aids, Technology, Pharmaceutical, Chromatography, Thin Layer, Warfarin, Powders, Tablets

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