Effect of Temperature on Solubilization and Hydrolytic Degradation of Solubilized Benzocaine and Homatropine
Copyright policy )Effect of Temperature on Solubilization and Hydrolytic Degradation of Solubilized Benzocaine and Homatropine
Abstract The solubilization of benzocaine with polyoxyethylene (23) lauryl ether and polysorbate 80 was determined as a function of temperature. The enhancement of the stability of benzocaine and homatropine solubilized with from 3 to 15% polyoxyethylene (23) lauryl ether and polysorbate 80 was quantitatively determined at 30, 50, and 70°. For the alkaline hydrolysis of benzocaine and homatropine, the logarithm of the specific rate constant is linearly related to the percent of the surface-active agent. The specific rate constant for the hydrolysis of benzocaine is linearly related to the reciprocal of the apparent solubility of benzocaine in polyoxy-ethylene (23) lauryl ether and polysorbate 80.
- University of Iowa United States
Kinetics, Surface-Active Agents, Solubility, Benzocaine, Hydrolysis, Temperature, Half-Life, Tropanes
Kinetics, Surface-Active Agents, Solubility, Benzocaine, Hydrolysis, Temperature, Half-Life, Tropanes
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