Entropic Factor in the Solubility of Small Particles

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1971 English Publisher:Elsevier BVJournal:Journal of Pharmaceutical Sciences, volume 60, pages 130-131 (issn: 0022-3549,

Copyright policy )

Authors: V F, Smolen; D O, Kildsig;

doi: 10.1002/jps.2600600129

pmid: 5548223

Entropic Factor in the Solubility of Small Particles

- Summary
- Subjects
- Metrics

Abstract

A mechanistic basis for the dependence of solubility on particle size was investigated. The solubility difference between a crystalline and microcrystalline solid was determined; the microcrystalline solid had a greater solubility than the crystalline. The heat of solution, as determined from a Van't Hoff plot, was found to be independent of particle size. The observed solubility difference was interpreted to be due to a relatively greater entropy of solution for the microcrystalline solid as compared to the crystalline solid.

Related Organizations

Purdue University West Lafayette
United States
Purdue University System
United States

Keywords

Chemistry, Chemical Phenomena, Solubility, Temperature, Griseofulvin, Mathematics

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	4
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average