Cyclic Analog of Ethacrynic Acid

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 1970 English Publisher:Elsevier BVJournal:Journal of Pharmaceutical Sciences, volume 59, pages 869-870 (issn: 0022-3549,

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Authors: M B, Floyd; G R, Allen;

doi: 10.1002/jps.2600590637

pmid: 5423099

Cyclic Analog of Ethacrynic Acid

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Abstract

The α,β-unsaturated ketone (4,4-dimethyl-2-ethyl-1[4H]-naphthalenon-6-yl)oxyacetic acid (III), a cyclic analog of ethacrynic acid, has been prepared, and its diuretic activity on oral administration to rats and dogs has been evaluated. No significant activity was observed.

Related Organizations

American Cyanamid
United States

Keywords

Dogs, Ethacrynic Acid, Spectrophotometry, Ultraviolet Rays, Animals, Diuresis, Rats

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