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Placental Transfer of Pentobarbital in the Rat

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 1970Publisher:Elsevier BVJournal:Journal of Pharmaceutical Sciences, volume 59, pages 803-805 (issn: 0022-3549,

Authors: David P.S. Mork; Stanley M. Shaw; Wayne V. Kessler;

doi: 10.1002/jps.2600590617

pmid: 5423082

Placental Transfer of Pentobarbital in the Rat

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Abstract

The placental transfer of pentobarbital and/or metabolites was determined in rats using 14C-labeled pentobarbital. The level of pentobarbital and/or metabolites in fetal blood was greatly influenced by the circulating level of pentobarbital and/or metabolites in the mother. Of the total pentobarbital and/or metabolites transferred, the percentage of unbound pentobarbital in fetal blood plasma was influenced by the pentobarbital dose level administered to the pregnant rat. A greater percentage of total pentobarbital and/or metabolites was present as unbound pentobarbital in fetal blood plasma than in maternal blood plasma. Chronic administration of pentobarbital during gestation decreased sensitivity to the pharmacological effects of further drug administration to the newborn. The changes induced by pretreatment were not permanent.

Related Organizations

Purdue University West Lafayette
United States
Purdue University System
United States

Keywords

Carbon Isotopes, Time Factors, Placenta, Rats, Fetus, Animals, Newborn, Pregnancy, Animals, Female, Chromatography, Thin Layer, Sleep, Maternal-Fetal Exchange, Pentobarbital

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