Simultaneous determination of dissolution and partitioning rates in vitro

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 1967 English Publisher:Elsevier BVJournal:Journal of Pharmaceutical Sciences, volume 56, pages 943-947 (issn: 0022-3549,

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Authors: P J, Niebergall; M Y, Patil; E T, Sugita;

doi: 10.1002/jps.2600560803

pmid: 6035340

Simultaneous determination of dissolution and partitioning rates in vitro

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Abstract

An in vitro method is presented for the simultaneous determination of the dissolution and partitioning rates of drugs. The kinetics of the system is described, and a number of methods are given for evaluating the rate constants. The effects of stirring rate and temperature upon the rate constants were investigated and found to be in agreement with what would be expected for diffusion-controlled processes.

Related Organizations

University of the Sciences
United States

Keywords

Kinetics, Solubility, Spectrophotometry, Salicylates

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