
pmid: 5862526
An improved holder for use in rotational disk dissolution studies has been developed. The compression die becomes the rotating member. With it, the relative intrinsic dissolution rates at 37° in 0.1 N HC1 with 430 r.p.m. rotational speed have been found to be caffeine monohydrate, 106, aspirin, 9.73, salicylamide, 12.3, and acetaminophen, 41.7, μmoles/cm. 2 /min.
Chemistry, Pharmaceutical
Chemistry, Pharmaceutical
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