Acid Stability of Lincomycin

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 1965 English Publisher:Elsevier BVJournal:Journal of Pharmaceutical Sciences, volume 54, pages 476-477 (issn: 0022-3549,

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Authors: A A, FORIST; L W, BROWN; M E, ROYER;

doi: 10.1002/jps.2600540338

pmid: 14301594

Acid Stability of Lincomycin

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Abstract

Lincomycin degrades slowly in 0.1 N HCl at 70° (half-life, 39 hr.), and the decrease in optical rotation shows a direct correlation with microbiological assays. At 37°, lincomycin shows no degradation for at least 48 hr. in 0.1 N HCl. Under these conditions, penicillin V degrades with a half-life of 29 min.

Keywords

Chemistry, Pharmaceutical, Research, Dermatologic Agents, Pharmacy, Acids, Antibiotics, Antitubercular, Anti-Bacterial Agents, Lincomycin

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