The objective of this present study is the synthesis of certain new 2-thiophene derivatives to be evaluated as potential antispasmodic, analgesic, or local anesthetic agents. The first part of this study concerns the synthesis of β-aminoketones (Mannich bases). The second segment concerns the synthesis of γ-amino secondary alcohols by chemical reduction of the corresponding β-aminoketones. The third portion describes the synthesis of a series of γ-amino tertiary alcohols by application of the Grignard reaction to the corresponding Mannich bases. The last section of the study involves the preparation of γ-aminoalkyl esters from the corresponding tertiary alcohols.