AbstractBackgroundBehçet's disease (BD) pathogenesis involves severe outcomes such as blindness, central nervous system manifestations, and deep venous thrombosis that impacts systemic and local inflammatory changes. We tested the hypothesis that BD negatively affects gingival health and increases the severity of gingivitis.MethodsThe study included 37 BD patients with gingivitis without any sign of periodontitis. Systemically healthy 19 patients with gingivitis (G) and 20 periodontally and systemically healthy individuals (C) were recruited as controls. BD patients were further grouped as stable and unstable based on their responses to BD treatment. Clinical periodontal parameters were measured to determine the impact of BD on gingival health. Serum and saliva levels of ELA‐2 (neutrophil elastase‐2), SLPI (secretory leukocyte protease inhibitor), α1‐AT (alpha1‐anti‐trypsin), VEGF (vascular endothelial growth factor), IL‐6 (interleukin‐6), IL‐8 (interleukin‐8), and TNF‐α (tumor necrosis factor alpha) were analyzed using multiplex immunoassay to measure the systemic and local inflammatory impact of BD.ResultsPlaque index (PI), probing pocket depth (PPD), and bleeding on probing (BOP) were significantly higher in the BD group than in the controls (p < 0.05). IL‐6 was higher in both serum and saliva in the BD group than in the G group (p < 0.05). ELA‐2 levels in saliva were higher in the stable BD group than in the controls, while TNF‐α and SLPI were statistically significantly higher in BD than in the control (p < 0.05). Salivary α1‐AT level was statistically lower in the BD group compared to the control group.ConclusionOur study suggested that the gingival inflammatory profile was impaired in patients with BD.