Keratan sulfate exacerbates experimental autoimmune encephalomyelitis
Copyright policy )Keratan sulfate exacerbates experimental autoimmune encephalomyelitis
Proteoglycans (PGs) are the components of extracellular matrices in the central nervous system (CNS). Keratan sulfate (KS) is a glycosaminoglycan that is included in the KSPG that acts as an inhibitory factor in nerve regeneration after CNS injury. To investigate the role of KS in immune diseases, we induced experimental autoimmune encephalomyelitis (EAE) in mice that were deficient in the N‐acetylglucosamine (GlcNAc)‐6‐O‐sulfotransferase 1 (GlcNAc6ST1) gene (KS‐KO). KS‐KO mice developed less severe EAE and showed repressed recall response in the induction phase. Furthermore, GlcNAc6ST1 might have roles in the passage of the pathogenic lymphocytes through the blood–brain barrier via adhesion molecules. Thus, modulation of KS may become a treatment for neuroimmunological diseases. © 2015 Wiley Periodicals, Inc.
- Kindai University Japan
- National Defense Medical College Japan
- Nagoya University Japan
Mice, Knockout, Carbohydrate Sulfotransferases, Encephalomyelitis, Autoimmune, Experimental, T-Lymphocytes, Freund's Adjuvant, Down-Regulation, Adoptive Transfer, Peptide Fragments, Mice, Inbred C57BL, Disease Models, Animal, Mice, Keratan Sulfate, Animals, Cytokines, Myelin-Oligodendrocyte Glycoprotein, Sulfotransferases, Cell Proliferation
Mice, Knockout, Carbohydrate Sulfotransferases, Encephalomyelitis, Autoimmune, Experimental, T-Lymphocytes, Freund's Adjuvant, Down-Regulation, Adoptive Transfer, Peptide Fragments, Mice, Inbred C57BL, Disease Models, Animal, Mice, Keratan Sulfate, Animals, Cytokines, Myelin-Oligodendrocyte Glycoprotein, Sulfotransferases, Cell Proliferation
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).8 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!