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Journal of Medical Virology
Article . 2021 . Peer-reviewed
License: CC BY
Data sources: Crossref
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Journal of Medical Virology
Article
License: CC BY
Data sources: UnpayWall
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PubMed Central
Article . 2021
License: CC BY
Data sources: PubMed Central
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Molecular characterization of non‐polio enteroviruses isolated from acute flaccid paralysis patients in Uganda

Authors: Phionah Tushabe; Wayne Howard; Josephine Bwogi; Molly Birungi; James P. Eliku; Proscovia Kakooza; Henry Bukenya; +9 Authors

Molecular characterization of non‐polio enteroviruses isolated from acute flaccid paralysis patients in Uganda

Abstract

AbstractEnteroviruses (EVs) are RNA viruses that can cause many clinical syndromes including acute flaccid paralysis (AFP). Within the global polio laboratory network, EVs are categorized either as polioviruses or non‐polio enteroviruses (NPEVs). Specific NPEVs have been described in polio‐like residual paralytic events in AFP patients. Retrospective analysis of 112 NPEV isolates from AFP patients was performed and thirty one NPEV types were identified of which 91% wereEnterovirus Band 9% wereEnterovirus Aspecies. The NPEVs were distributed across the country with most patients in the eastern region (41/89; 46.1%). The highest proportion of patients were children less than 5 years (77/89; 86.5%) and male patients were more common (54/89; 60.7%). Echovirus 11 (11/89; 12.4%) was frequently observed and phylogenetic analysis of these sequences revealed high diversity. Coxsackievirus B5 (CV‐B5), CV‐B6, E21, and EV‐B69 were only seen in patients with residual paralysis. Analyses of the EV‐A71 sequence indicated a unique genogroup.

Keywords

Male, Adolescent, Genotype, Genetic Variation, Neuromuscular Diseases, Sequence Analysis, DNA, Myelitis, Feces, Cross-Sectional Studies, Child, Preschool, Epidemiological Monitoring, Central Nervous System Viral Diseases, Enterovirus Infections, Humans, Female, Child, Research Articles, Phylogeny, Enterovirus, Poliomyelitis, Retrospective Studies

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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    6
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
6
Top 10%
Average
Top 10%
Green
hybrid