An introduction to quadrupole–time‐of‐flight mass spectrometry
Copyright policy )An introduction to quadrupole–time‐of‐flight mass spectrometry
AbstractA brief introduction is presented to the basic principles and application of a quadrupole–time‐of‐flight (TOF) tandem mass spectrometer. The main features of reflecting TOF instruments with orthogonal injection of ions are discussed. Their operation and performance are compared with those of triple quadrupoles with electrospray ionization and matrix‐assisted laser desorption/ionization (MALDI) TOF mass spectrometers. Examples and recommendations are provided for all major operational modes: mass spectrometry (MS) and tandem MS (MS/MS), precursor ion scans and studies of non‐covalent complexes. Basic algorithms for liquid chromatography/MS/MS automation are discussed and illustrated by two applications. Copyright © 2001 John Wiley & Sons, Ltd.
Spectrometry, Mass, Electrospray Ionization, Reproducibility of Results, Equipment Design, Mass Spectrometry, Peptide Fragments, Calibration, Animals, Insulin, Cattle, Amino Acid Sequence
Spectrometry, Mass, Electrospray Ionization, Reproducibility of Results, Equipment Design, Mass Spectrometry, Peptide Fragments, Calibration, Animals, Insulin, Cattle, Amino Acid Sequence
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