2D Ultrashort Echo‐Time Functional Lung Imaging
Copyright policy )2D Ultrashort Echo‐Time Functional Lung Imaging
BackgroundImaging of the lung by MRI is challenging due to the intrinsic low proton density and rapid T2* relaxation. MRI methods providing lung parenchyma and function are in demand.PurposeTo investigate the feasibility of two‐dimensional ultrashort echo‐time (2D UTE) imaging for lung function assessment.Study TypeProspective.PopulationEleven healthy volunteers.Field Strength/Sequence3T, 2D tiny golden angle UTE (2D‐tyUTE).AssessmentThe applicability of breath‐hold (BH) and self‐gated (SG) 2D‐tyUTE for quantification of the lung parenchyma signal‐to‐noise ratio (SNR), proton fraction (fP), fractional ventilation (FV), and perfusion (f) was investigated. Dependencies on repetition time (BHS/I1/I2) and respiratory phase (expiration [EX], inspiration [IN]) were investigated and compared between smokers and nonsmokers.Statistical TestsAnalysis of variance (ANOVA), Kendell's W.ResultsSignificant differences of SNR (EX: 10.98 ± 3.19(BHS), 14.58 ± 3.89(BHI1), 17.59 ± 4.92(BHI2), 11.00 ± 5.42(SG); IN: 7.17 ± 2.07(BHS), 9.51 ± 2.37(BHI1), 10.49 ± 2.33(BHI2), 10.00 ± 4.14(SG)) (P < 0.05 for all cases) were observed between the different approaches. Where fP in expiration (0.41 ± 0.13) was independent of the BH imaging technique, it was slightly higher in SG (0.44 ± 0.06). FV was reproducible among the BH techniques (0.41 ± 0.10), but significantly lower in SG (0.21 ± 0.06) (P < 0.05). A moderate correlation (R2 = 0.47, P < 0.01) was observed between the breathing amplitude and FV. No significant differences between BH and SG were observed for the perfusion analysis (EX: 3.50 ± 1.29 mL/min/mL [BHS]; IN: 2.36 ± 1.05 mL/min/mL [BHS]). Significant differences in fP were found between smokers (0.48 ± 0.11 BH) and nonsmokers (0.37 ± 0.12 BH) in expiration.Data ConclusionThis study demonstrates the feasibility of 2D‐tyUTE for successful quantification of relevant lung function parameters at 3T within clinically attractive acquisition times. The low spatial resolution into the slice selection direction may limit the final sensitivity and needs further clinical evaluation.Level of Evidence2Technical Efficacy Stage1 J. MAGN. RESON. IMAGING 2020;52:1637–1644.
- University of Ulm Germany
Kernspintomografie, Lunge, Signal-To-Noise Ratio, fractional ventilation, Magnetic Resonance Imaging, perfusion, breath‐hold, Magnetic resonance imaging, Bildgebendes Verfahren, Imaging, Three-Dimensional, 2D UTE, Image Processing, Computer-Assisted, Humans, Prospective Studies, proton density, Lung; Diagnostic imaging, self‐gating, Lung, MRI, info:eu-repo/classification/ddc/610
Kernspintomografie, Lunge, Signal-To-Noise Ratio, fractional ventilation, Magnetic Resonance Imaging, perfusion, breath‐hold, Magnetic resonance imaging, Bildgebendes Verfahren, Imaging, Three-Dimensional, 2D UTE, Image Processing, Computer-Assisted, Humans, Prospective Studies, proton density, Lung; Diagnostic imaging, self‐gating, Lung, MRI, info:eu-repo/classification/ddc/610
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