Inactivation of interleukin-8 by aminopeptidase N (CD13)
Copyright policy )Inactivation of interleukin-8 by aminopeptidase N (CD13)
Abstract Aminopeptidase (APN) was found to degrade interleukin-8 (IL-8) and inactivate its chemotactic activity. The chemotactic activity of IL-8 was decreased by APN or neutrophil plasma membranes dose- and time-dependently. The chemotactic activity was not inactivated in the presence of bestatin or WM15 monoclonal antibody. The expression of IL-8 was measured by flow cytometry. On lipopolysaccharide (LPS) stimulation, IL-8 expression increased for 60 min and then decreased markedly. In contrast, on treatment with LPS and bestatin, the expression of IL-8 increased continuously for at least 120 min. These results suggest that the expression and release of IL-8 from phagocytic cells are regulated by the proteolytic effect of APN on IL-8. J. Leukoc. Biol. 57: 129–134; 1995.
Lipopolysaccharides, Time Factors, Dose-Response Relationship, Drug, Neutrophils, Swine, Cell Membrane, Interleukin-8, Antibodies, Monoclonal, CD13 Antigens, Flow Cytometry, Recombinant Proteins, Chemotaxis, Leukocyte, Leucine, Leukocytes, Mononuclear, Animals, Humans, Electrophoresis, Polyacrylamide Gel, Protease Inhibitors
Lipopolysaccharides, Time Factors, Dose-Response Relationship, Drug, Neutrophils, Swine, Cell Membrane, Interleukin-8, Antibodies, Monoclonal, CD13 Antigens, Flow Cytometry, Recombinant Proteins, Chemotaxis, Leukocyte, Leucine, Leukocytes, Mononuclear, Animals, Humans, Electrophoresis, Polyacrylamide Gel, Protease Inhibitors
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