HIV-1 envelope protein gp120 affects phenotype and function of monocytes in vitro
Copyright policy )HIV-1 envelope protein gp120 affects phenotype and function of monocytes in vitro
Abstract We investigated the effect of human immunodeficiency virus type 1 (HIV-1) recombinant gp120 (rec.gp120) on phenotype and function of cultured monocytes. Rec.gp120 significantly reduced the accessory function of monocytes to stimulate autologous lymphocytes with anti-CD3, the Fc receptor–mediated chemiluminescence of monocytes, and the expression of CD4 and Fc receptor I/II, while the expression of the monocyte marker GD14 and major histocompatibility complex class I and II was not influenced. According to these phenotypic results, preincubation of monocytes with rec.gp120 depressed anti-CD3 antibody-induced T cell stimulation and Fc receptor-mediated phagocytosis as determined by chemiluminescence. Interferon-γ release of lymphocytes induced by purified protein derivative of tuberculin was enhanced by gp120. These effects of isolated gp120 on monocyte immune functions in vitro might contribute to the understanding of the pathophysiology of HIV-1 infection in viva J. Leukoc. Biol. 55: 545–551; 1994.
Antigen Presentation, Interleukin-6, HIV Infections, Receptors, Fc, HIV Envelope Protein gp120, In Vitro Techniques, Lymphocyte Activation, Tuberculin, Monocytes, Phenotype, CD4 Antigens, Luminescent Measurements, Humans
Antigen Presentation, Interleukin-6, HIV Infections, Receptors, Fc, HIV Envelope Protein gp120, In Vitro Techniques, Lymphocyte Activation, Tuberculin, Monocytes, Phenotype, CD4 Antigens, Luminescent Measurements, Humans
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).21 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!