Abstract Invasive meningococcal disease due to Neisseria meningitidis in the United States has decreased since the late 1990s, leading to fewer practicing clinicians with first‐hand experience in diagnosing and managing of the disease. However, since 2021, cases have increased, creating an urgency for clinicians to familiarize themselves with the signs and sequelae of severe invasive meningococcal disease and stay up to date with current vaccine recommendations. This review summarizes recent literature and guidance for clinicians on the prevention, early recognition, and management of this vaccine‐preventable disease.