AbstractA 55 year‐old man with type 2 diabetes mellitus presented to the emergency department with subacute nausea, vomiting, and abdominal pain. He was found to have epididymitis and hyperglycemia that improved with antibiotics and supportive care. However, he was also discovered to have significant acute kidney injury and chronic, relapsing‐remitting bouts of eye pain and redness, confirmed to be uveitis on ophthalmologic evaluation. Despite completing an appropriate course of antibiotics, his pyuria and kidney injury persisted. An extensive infectious, autoimmune, and malignancy work‐up was negative. As such, renal biopsy was pursued and revealed findings consistent with tubulointerstitial nephritis. With a negative secondary work‐up, he was diagnosed with tubulointerstitial nephritis and uveitis (TINU) syndrome.