New and convergent synthesis of saflufenacil

descriptionPublicationkeyboard_double_arrow_right Article 09 Dec 2019 English Publisher:WileyJournal:Journal of Heterocyclic Chemistry, volume 57, pages 151-156 (issn: 0022-152X, eissn: 1943-5193,

Copyright policy )

Authors: Bin Wang; Yongjun Mao; Xiangyu Liu; Zhiwei Zhao; Lehao Bu; Han Wang;

doi: 10.1002/jhet.3757

New and convergent synthesis of saflufenacil

- Summary
- Metrics

Abstract

AbstractA new, practical, and hundred‐gram scale synthesis of saflufenacil, a protoporphyrinogen oxidase (PPO) inhibitor herbicide, is described. The key intermediate N‐methyl‐N‐isopropyl sulfamide (12) is obtained from sulfuryl chloride isocyanate, t‐butanol, and N‐methyl‐N‐isopropylamine in 74.8% yield over 3 steps. Saflufenacil is prepared in 48.6% yield over 8 steps and 98.7% purity (HPLC).

Related Organizations

Shanghai University of Engineering Sciences
China (People's Republic of)

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	5
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average