Immune response to COVID‐19 vaccination in patients with Waldenström macroglobulinaemia who pause their BTKi therapy
Copyright policy )Immune response to COVID‐19 vaccination in patients with Waldenström macroglobulinaemia who pause their BTKi therapy
AbstractPatients with Waldenström macroglobulinaemia (WM) are at increased risk of severe COVID‐19 infection and have poor immune responses to COVID‐19 vaccination. This study assessed whether a closely monitored pause in Bruton's Tyrosine Kinase inhibitor (BTKi) therapy might result in an improved humoral response to a 3rd COVID‐19 vaccine dose. Improved response was observed in WM patients who paused their BTKi, compared to a group who did not pause their BTKi. However, the response was attenuated after BTKi recommencement. This data contributes to our understanding of vaccination strategies in this patient group and may help inform consensus approaches in the future.
- Children's Hospital at Westmead Australia
- The University of Sydney, Library Australia
- Westmead Hospital Australia
- Kirby Institute Australia
- Calvary Mater Newcastle Hospital Australia
Coronaviruses, Prevention, Coronaviruses Vaccines, 610, 32 Biomedical and Clinical Sciences, 3 Good Health and Well Being, lymphoma, vaccines, 3204 Immunology, Vaccine Related, anzsrc-for: 3105 Genetics, Emerging Infectious Diseases, Infectious Diseases, anzsrc-for: 32 Biomedical and Clinical Sciences, 3.4 Vaccines, Short Reports, Clinical Research, Waldenström macroglobulinaemia, Immunization, Diseases of the blood and blood-forming organs, RC633-647.5, anzsrc-for: 3204 Immunology, anzsrc-for: 3201 Cardiovascular medicine and haematology
Coronaviruses, Prevention, Coronaviruses Vaccines, 610, 32 Biomedical and Clinical Sciences, 3 Good Health and Well Being, lymphoma, vaccines, 3204 Immunology, Vaccine Related, anzsrc-for: 3105 Genetics, Emerging Infectious Diseases, Infectious Diseases, anzsrc-for: 32 Biomedical and Clinical Sciences, 3.4 Vaccines, Short Reports, Clinical Research, Waldenström macroglobulinaemia, Immunization, Diseases of the blood and blood-forming organs, RC633-647.5, anzsrc-for: 3204 Immunology, anzsrc-for: 3201 Cardiovascular medicine and haematology
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