YTHDF1 facilitates PRC1‐mediated H2AK119ub in human ES cells
Copyright policy )YTHDF1 facilitates PRC1‐mediated H2AK119ub in human ES cells
AbstractPolycomb repressive complexes (PRCs) play critical roles in cell fate decisions during normal development as well as disease progression through mediating histone modifications such as H3K27me3 and H2AK119ub. How exactly PRCs recruited to chromatin remains to be fully illuminated. Here, we report that YTHDF1, the N6‐methyladenine (m6A) RNA reader that was previously known to be mainly cytoplasmic, associates with RNF2, a PRC1 protein that mediates H2AK119ub in human embryonic stem cells (hESCs). A portion of YTHDF1 localizes in the nuclei and associates with RNF2/H2AK119ub on a subset of gene loci related to neural development functions. Knock‐down YTHDF1 attenuates H2AK119ub modification on these genes and promotes neural differentiation in hESCs. Our findings provide a noncanonical mechanism that YTHDF1 participates in PRC1 functions in hESCs.
- Guangzhou Laboratory China (People's Republic of)
- Chinese Academy of Sciences China (People's Republic of)
- University of Chinese Academy of Sciences China (People's Republic of)
- Guangzhou Institutes of Biomedicine and Health China (People's Republic of)
- Shanghai Institute for Science of Science China (People's Republic of)
Polycomb Repressive Complex 1, Histones, Human Embryonic Stem Cells, Humans, Polycomb-Group Proteins, RNA-Binding Proteins, Cell Cycle Proteins, Protein Processing, Post-Translational, Chromatin
Polycomb Repressive Complex 1, Histones, Human Embryonic Stem Cells, Humans, Polycomb-Group Proteins, RNA-Binding Proteins, Cell Cycle Proteins, Protein Processing, Post-Translational, Chromatin
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