ncRNAs associated with drug resistance and the therapy of digestive system neoplasms
Copyright policy )ncRNAs associated with drug resistance and the therapy of digestive system neoplasms
AbstractDigestive system cancer remains a common cancer and the main cause of cancer‐related death worldwide. Drug resistance is a major challenge in the therapy of digestive system cancer, and represents a primary obstacle in the treatment of cancer by restricting the efficiency of both traditional chemotherapy and biological therapies. Existing studies indicate that noncoding RNAs play an important role in the evolution and progression of drug resistance in digestive system cancer, mainly by modulating drug transporter‐related proteins, DNA damage repair, cell‐cycle‐related proteins, cell apoptosis‐related proteins, drug target‐related proteins, and the tumor microenvironment. In this review, we address the potential mechanisms of ncRNAs underlying drug resistance in digestive system tumors and discuss the possible application of ncRNAs against drug resistance in digestive system tumors.
- Affiliated Hospital of Nantong University China (People's Republic of)
- Nantong University China (People's Republic of)
RNA, Untranslated, DNA Repair, Digestive System Neoplasms, Gene Expression Regulation, Neoplastic, MicroRNAs, Drug Resistance, Neoplasm, Biomarkers, Tumor, Tumor Microenvironment, Humans, DNA Damage
RNA, Untranslated, DNA Repair, Digestive System Neoplasms, Gene Expression Regulation, Neoplastic, MicroRNAs, Drug Resistance, Neoplasm, Biomarkers, Tumor, Tumor Microenvironment, Humans, DNA Damage
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