LncRNA–CDC6 promotes breast cancer progression and function as ceRNA to target CDC6 by sponging microRNA‐215
Copyright policy )LncRNA–CDC6 promotes breast cancer progression and function as ceRNA to target CDC6 by sponging microRNA‐215
AbstractRapid proliferation and metastasis of breast cancers resulted in poor prognosis in clinic. Recent studies have proved that long noncoding RNAs (lncRNAs) were involved in tumor progression. In this study, we aimed to determine the roles and mechanisms of lncRNA–cell division cycle 6 (CDC6) in regulating proliferation and metastasis of breast cancer. Clinically, lncRNA–CDC6 was highly expressed in tumor tissues and was positively correlated with clinical stages of breast cancers. Functionally, the ectopic expression of lncRNA–CDC6 promoted proliferation via regulation of G1 phase checkpoint, and further promoting the migration capability. Moreover, lncRNA–CDC6 could function as competitive endogenous RNA (ceRNA) via directly sponging of microRNA‐215 (miR‐215), which further regulating the expression of CDC6. Taken together, our results proved that lncRNA–CDC6 could function as ceRNA and promote the proliferation and metastasis of breast cancer cells, which provided a novel prognostic marker for breast cancers in clinic.
- Shandong Women’s University China (People's Republic of)
Nuclear Proteins, Breast Neoplasms, Cell Cycle Proteins, G1 Phase Cell Cycle Checkpoints, Gene Expression Regulation, Neoplastic, MicroRNAs, Cell Movement, Disease Progression, MCF-7 Cells, Humans, Female, Neoplasm Invasiveness, RNA, Long Noncoding, Cell Proliferation, Signal Transduction
Nuclear Proteins, Breast Neoplasms, Cell Cycle Proteins, G1 Phase Cell Cycle Checkpoints, Gene Expression Regulation, Neoplastic, MicroRNAs, Cell Movement, Disease Progression, MCF-7 Cells, Humans, Female, Neoplasm Invasiveness, RNA, Long Noncoding, Cell Proliferation, Signal Transduction
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