The decline and fall of the IGF‐I receptor

descriptionPublicationkeyboard_double_arrow_right Article 20 Dec 2012 English Publisher:WileyJournal:Journal of Cellular Physiology, volume 228, pages 675-679 (issn: 0021-9541, eissn: 1097-4652,

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Authors: Renato, Baserga;

doi: 10.1002/jcp.24217

pmid: 22926508

The decline and fall of the IGF‐I receptor

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Abstract

AbstractThis review examines the effect of targeting the insulin‐like growth factor 1 receptor (IGF‐IR) in human cancers. The results are disappointing. The causes for the failure are discussed, as well as the possible use of the IGF‐IR as a secondary target. J. Cell. Physiol. 228: 675–679, 2013. © 2012 Wiley Periodicals, Inc.

Related Organizations

Thomas Jefferson University
United States
Kimmel Cancer Center
United States

Keywords

Neoplasms, Animals, Humans, Antineoplastic Agents, Molecular Targeted Therapy, Receptor, IGF Type 1

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