Nuclear translocation of insulin receptor substrate‐1 by the insulin receptor in mouse embryo fibroblasts
Copyright policy )Nuclear translocation of insulin receptor substrate‐1 by the insulin receptor in mouse embryo fibroblasts
AbstractTranslocation of the insulin receptor substrate‐1 (IRS‐1) to the nuclei has been reported to occur in cells stimulated by insulin‐like growth factor‐1 (IGF‐I) or expressing certain viral and cellular oncogenes. We show here that insulin can also induce nuclear translocation of IRS‐1 in mouse embryo fibroblasts (MEF), that do not express the type 1 insulin‐like growth factor receptor (IGF‐IR). Only the A isoform of the insulin receptor (IR) can induce IRS‐1 nuclear translocation, which is significant when the receptor is over‐expressed. At physiological receptor levels, translocation occurs only in a fraction of cells, and only at high concentrations of ligand. © 2003 Wiley‐Liss, Inc.
- Kimmel Cancer Center United States
- University of Catania Italy
- Thomas Jefferson University United States
- Ospedale Garibaldi Italy
Cell Nucleus, Microscopy, Confocal, Active Transport, Cell Nucleus, Fibroblasts, Embryo, Mammalian, Phosphoproteins, Immunohistochemistry, Receptor, Insulin, Cell Line, Receptor, IGF Type 1, Mice, Antigens, CD, Insulin-Like Growth Factor II, Gene Targeting, Insulin Receptor Substrate Proteins, Animals, Insulin
Cell Nucleus, Microscopy, Confocal, Active Transport, Cell Nucleus, Fibroblasts, Embryo, Mammalian, Phosphoproteins, Immunohistochemistry, Receptor, Insulin, Cell Line, Receptor, IGF Type 1, Mice, Antigens, CD, Insulin-Like Growth Factor II, Gene Targeting, Insulin Receptor Substrate Proteins, Animals, Insulin
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