Biochemical properties and progress in cancers of tRNA‐derived fragments

descriptionPublicationkeyboard_double_arrow_right Article 31 Oct 2019 English Publisher:WileyJournal:Journal of Cellular Biochemistry, volume 121, pages 2,058-2,063 (issn: 0730-2312, eissn: 1097-4644,

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Authors: Zhongliang Ma; Jinbao Zhou; Yang Shao; Fatemah.A. Jafari; Pengfei Qi; Yanli Li;

doi: 10.1002/jcb.29492

pmid: 31674076

Biochemical properties and progress in cancers of tRNA‐derived fragments

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Abstract

AbstracttRNA‐derived small RNAs (tRFs), a kind of noncoding RNAs, are generated from transfer RNAs. tRFs have some types according to their source and sizes. They play important roles in cell life and carcinogenesis. In this paper, we review the biogenesis and biological properties. We also focus on current progress of tRFs and some tsRNAs such as tRF‐Leu‐CAG, which have been studied or will be further investigated in tumorgenesis and diagnostic biomarkers in the clinic.

Related Organizations

Shanghai University
China (People's Republic of)
Shanghai University
China (People's Republic of)

Keywords

Gene Expression Regulation, Neoplastic, RNA, Transfer, Neoplasms, RNA Precursors, Humans

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