Cation‐independent mannose 6‐phosphate receptor contains covalently bound fatty acid
Copyright policy )Cation‐independent mannose 6‐phosphate receptor contains covalently bound fatty acid
AbstractThe cation‐independent mannose 6‐phosphate receptor (215,000 daltons) was isolated from embryonic bovine tracheal cells and embryonic human skin fibroblasts labelled with [3H]palmitic acid, the tritium label was detected in the protein upon fluorographic analysis of SDS‐polyacrylamide gels of the purified receptor. The label was not sensitive to hydroxylamine, methanolic KOH, or β‐mercaptoethanol, but labelled fatty acid was recovered from the protein by acidic methanolysis. Labelled receptor protein could not be isolated from cells grown in the presence of [3H]myristic acid. The results suggest the presence of amide‐linked palmitic acid in the structure of the cation‐independent mannose 6‐phosphate receptor.
- University of California, Los Angeles United States
Mannosephosphates, Palmitic Acid, Receptors, Cell Surface, Palmitic Acids, Myristic Acid, Receptor, IGF Type 2, Cell Line, Molecular Weight, Leucine, Animals, Humans, Myristic Acids, Protein Binding
Mannosephosphates, Palmitic Acid, Receptors, Cell Surface, Palmitic Acids, Myristic Acid, Receptor, IGF Type 2, Cell Line, Molecular Weight, Leucine, Animals, Humans, Myristic Acids, Protein Binding
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