Novel anti‐angiogenic peptides derived From ELR‐containing CXC chemokines
Copyright policy )Novel anti‐angiogenic peptides derived From ELR‐containing CXC chemokines
AbstractAngiogenesis is tightly regulated by numerous endogenous pro‐ and anti‐angiogenic proteins and peptides. Among these are the CXC chemokines, a set of multifunctional peptides. CXC chemokines containing the ELR motif act as pro‐angiogenic agents by regulating both endothelial cell proliferation and migration. Here we show that a set of six 22–24‐amino acid peptides derived from the pro‐angiogenic ELR‐containing CXC chemokines exhibit notable anti‐proliferative and anti‐migratory activity in vitro; we call these peptides chemokinostatins. The ability of the identified peptides to inhibit the basic components of angiogenesis even though they are derived from pro‐angiogenic proteins contributes towards the understanding of the diverse role of the CXC chemokine family in angiogenesis. J. Cell. Biochem. 104: 1356–1363, 2008. © 2008 Wiley‐Liss, Inc.
- Johns Hopkins University United States
- Johns Hopkins University School of Medicine United States
- JOHNS HOPKINS UNIVERSITY United States
- Johns Hopkins Medicine United States
Umbilical Veins, Amino Acid Motifs, Endothelial Cells, Angiogenesis Inhibitors, Peptide Fragments, Cell Movement, Humans, Peptides, Chemokines, CXC, Cells, Cultured, Cell Proliferation
Umbilical Veins, Amino Acid Motifs, Endothelial Cells, Angiogenesis Inhibitors, Peptide Fragments, Cell Movement, Humans, Peptides, Chemokines, CXC, Cells, Cultured, Cell Proliferation
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