ABSTRACT Delphinidin, a bioactive anthocyanidin found in pigmented fruits and vegetables, exhibits remarkable therapeutic potential due to its antioxidant, anti‐inflammatory, and anti‐cancer properties. This review synthesizes current knowledge on delphinidin's structure, dietary sources, stability challenges, and mechanisms of action. As a potent antioxidant, it scavenges reactive oxygen species (ROS) and upregulates endogenous defenses via the Nrf2 pathway, mitigating oxidative stress in chronic diseases. Delphinidin suppresses inflammation by inhibiting NF‐κB and MAPK signaling, reducing pro‐inflammatory cytokines like TNF‐α and IL‐6. Its anti‐cancer effects include apoptosis induction, cell cycle arrest, and inhibition of angiogenesis and metastasis through modulation of VEGF, MMPs, and PI3K/Akt pathways. Additionally, delphinidin demonstrates cardioprotective effects by enhancing endothelial function and reducing LDL oxidation, while its neuroprotective actions involve attenuating neuroinflammation and amyloid‐β aggregation in neurodegenerative disorders. The compound also improves metabolic health by enhancing insulin sensitivity and inhibiting α‐glucosidase. However, delphinidin's pH and thermal instability limit its clinical application, prompting research into encapsulation and nano‐delivery systems to enhance bioavailability. This review underscores delphinidin's promise as a nutraceutical or adjunctive therapy while highlighting the need for further studies to validate its efficacy in humans and optimize delivery methods.