AbstractIt has recently been found that alloying with copper improved the inherently poor grindability and wear resistance of titanium. This study characterized the corrosion behavior of cast Ti‐6Al‐4V alloyed with copper. Alloys (0.9 or 3.5 mass % Cu) were cast with the use of a magnesia‐based investment in a centrifugal casting machine. Three specimen surfaces were tested: ground, sandblasted, and as cast. Commercially pure titanium and Ti‐6Al‐4V served as controls. Open‐circuit potential measurement, linear polarization, and potentiodynamic cathodic polarization were performed in aerated (air + 10% CO2) modified Tani‐Zucchi synthetic saliva at 37°C. Potentiodynamic anodic polarization was conducted in the same medium deaerated by N2 + 10% CO2. Polarization resistance (Rp), Tafel slopes, and corrosion current density (Icorr) were determined. A passive region occurred for the alloy specimens with ground and sandblasted surfaces, as for CP Ti. However, no passivation was observed on the as‐cast alloys or on CP Ti. There were significant differences among all metals tested for Rp and Icorr and significantly higher Rp and lower Icorr values for CP Ti compared to Ti‐6Al‐4V or the alloys with Cu. Alloying up to 3.5 mass % Cu to Ti‐6Al‐4V did not change the corrosion behavior. Specimens with ground or sandblasted surfaces were superior to specimens with as‐cast surfaces. © 2005 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater